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Search Results for " chloride channel "

39

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12608	QX-314 chloride	Sodium Channel	Membrane transporter/Ion channel
	QX-314 chloride 是钠离子通道电荷阻滞剂，具有膜不渗透性。
T8960	MONNA	Chloride channel	Membrane transporter/Ion channel
	MONNA 是 TMEM16A (Anoctamin-1)阻滞剂，IC50为 80 nM。它在氯离子存在或不存在的情况下诱导啮齿动物抵抗动脉的血管舒张。
T15192	Eact	Chloride channel	Membrane transporter/Ion channel
	Eact 是一种选择性和有效的 TMEM16A 激活剂，可直接激活感觉伤害感受器中的 TRPV1 通道，还会产生瘙痒、急性伤害感受和热过敏。
T7638	NPPB	Chloride channel	Membrane transporter/Ion channel
	NPPB 是外向整流氯化物通道阻断剂，IC50 为 80 nM。
T10979	DCPIB	Potassium Channel; Chloride channel	Membrane transporter/Ion channel
	DCPIB 是选择性可逆体积调节性阴离子通道抑制剂，抑制肿胀激活氯电流，在 CPAE 细胞中，IC50值为 4.1 μM。它能够电压依赖性激活钾离子通道 TREK1 和 TRAAK，抑制 TRESK、TASK1 和 TASK3的 IC50值分别为 0.14、0.95 和 50.72 μM。
T7538	Tetraethylammonium chloride	Potassium Channel	Membrane transporter/Ion channel
	Tetraethylammonium chloride 是非选择性钾通道阻滞剂。它是有机阳离子转运蛋白的良好底物，并具有抗肿瘤特性。
T23213	QX-222 chloride QX 222,Lidocaine N-Methyl Hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	QX-222 chloride (Lidocaine N-Methyl Hydrochloride) 是 Lignocaine 的一种三甲基类似物，是有效的 Na+通道阻滞剂。
T8391	Cesium chloride 氯化铯,CsCl	Potassium Channel	Membrane transporter/Ion channel
	Cesium chloride (CsCl) 是一种钾通道抑制剂，可以防止 Alloxan 引起的 Na+转运减少。Cesium chloride 可以诱发心律失常。
T0979	Dequalinium chloride Dequafungan,地喹氯铵,Danical,Decabis	Potassium Channel; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel
	Dequalinium chloride (Decabis) 是一种apamin 敏感型的钾离子通道选择性阻断剂。
T16346	NS1652	Chloride channel	Membrane transporter/Ion channel
	NS1652 是可逆阴离子电导抑制剂，在人和小鼠的红细胞中，可以抑制氯离子通道，IC50值为 1.6 μM。
T13059	T16Ainh-A01	Chloride channel	Membrane transporter/Ion channel
	T16Ainh-A01 是氨基苯基噻唑，是有效的跨膜蛋白 16A 的抑制剂，抑制 TMEM16A 介导的氯离子电流，IC50约为1 µM。TMEM16A (ANO1)起钙激活氯离子通道(CaCC)的作用。
T15233	Endovion NS3728	Chloride channel	Membrane transporter/Ion channel
	Endovion (NS3728) 是阴离子通道抑制剂和 Anoctamin-1 (ANO 1) 通道抑制剂，也是特异性的 VRAC/VSOAC 阻断剂。
T7191	Diphenyleneiodonium chloride 二苯基氯化碘盐,DPI	NOS; Reactive Oxygen Species; NADPH; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Diphenyleneiodonium chloride (DPI) 是 NADPH 氧化酶抑制剂，也是 TRPA1激活剂，EC50为 1 - 3 μM 。它选择性抑制胞内活性氧。
T0858	Flufenamic acid Arlef,Nichisedan,氟灭酸,氟芬那酸,Achless	Potassium Channel; Calcium Channel; Chloride channel; COX; AMPK; Parasite	Chromatin/Epigenetic; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Flufenamic acid (Arlef) 是一种非甾体类抗炎剂，是一种邻氨基苯甲酸衍生物，具有镇痛、抗炎和解热的特性。它用于肌肉骨骼和关节疾病。
T0275	Meticrane 美替克仑,Fontiliz,Arresten,蒲硫杂茶磺胺	Chloride channel; Sodium Channel	Membrane transporter/Ion channel
	Meticrane (Arresten) 是一种磺胺类衍生物，具有类似噻嗪类利尿剂的活性，可于研究原发性高血压。
T2498	Adjudin AF-2364	Chloride channel; Mitochondrial Metabolism	Membrane transporter/Ion channel; Metabolism
	Adjudin (AF-2364) 是广泛研究的男性避孕试剂，可通过抑制 NF-κB 通路来减弱小胶质细胞的活化。
T4330	CaCCinh-A01	Chloride channel	Membrane transporter/Ion channel
	CaCCinh-A01 是钙激活氯离子通道和TMEM16A 抑制剂，IC50值分别为 10 和 2.1 μM。
T0693	Niflumic acid 氟尼酸,Nifluril,Forenol,Landruma	Others; Phospholipase; Chloride channel; COX; Monocarboxylate transporter; UGT	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	Niflumic acid (Nifluril) 是钙离子激活的氯离子通道阻断剂，用于治疗类风湿性关节炎的镇痛剂和抗炎剂。
T1049	Oxybutynin chloride Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl	Potassium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Oxybutynin chloride (Oxybutynin HCl) 是一种抗胆碱能药物，用于缓解泌尿和膀胱困难。它抑制血管 Kv 通道，IC50为 11.51 μM。
T13536	Afoxolaner	Chloride channel; GABA Receptor; Parasite	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Afoxolaner 是一种异恶唑啉杀虫剂/杀螨剂，可对抗犬的肩胛硬蜱。它作用于昆虫的 γ-氨基丁酸(GABA)受体谷氨酸受体，抑制 GABA 和谷氨酸调节的氯离子吸收，导致过度的神经元刺激和节肢动物死亡。
T4503	Talniflumate Somalgen,他尼氟酯	Chloride channel; COX; N-Acetylglucosaminyltransferase; Anion Exchanger	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Talniflumate (Somalgen) 是一种钙激活氯离子通道 (hCLCA1/mCLCA3) 阻滞剂，可减少动物模型和细胞培养中的粘蛋白合成和释放。它通过抑制环氧合酶，并抑制 Cl-/HCO3- 交换活性，具有抗炎作用。它还增加了远端肠梗阻综合征囊性纤维化小鼠模型的存活率。
T22330	Fenamic acid N-苯基邻氨基苯甲酸,2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid	Chloride channel	Membrane transporter/Ion channel
	Fenamic acid (N-Phenylanthranilic acid) 是氯通道阻滞剂。
T4059	Selamectin UK-124114,司拉克丁,塞拉菌素	Chloride channel; P-gp; Parasite	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Selamectin (UK-124114) 是半合成的大环内酯，是一种驱虫剂，可增强线虫中谷氨酸和 GABA 门控氯离子通道的开放。它还是抗寄生虫剂，可激活神经元和咽肌中的谷氨酸门控氯离子通道，以预防恶丝虫，淋巴丝虫和线虫感染。它还是 P-糖蛋白底物和抑制剂，IC50为 120 nM。
T6307	Lubiprostone 芦比前列酮,SPI-0211,RU-0211,鲁比前列酮	Chloride channel	Membrane transporter/Ion channel
	Lubiprostone (RU-0211) 是一种 ClC-2 氯化物通道的激活剂，用于治疗特发性慢性便秘。
T15212	Emamectin Benzoate MK-244,甲胺基阿维菌素苯甲酸盐	Apoptosis; Reactive Oxygen Species; GABA Receptor; Parasite	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	Emamectin Benzoate (MK-244) 是口服有效的神经系统毒物，其通过结合昆虫中的 GABA 受体发挥作用。它是阿维菌素的半合成衍生物之一，具有广谱的杀虫和杀螨活性。它诱导ROS 介导的 DNA 损伤和细胞凋亡。
T5454	N-(p-amylcinnamoyl) Anthranilic Acid 2-(3-(4-戊基苯基)丙烯酰胺基)苯甲酸,ACA	Phospholipase; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 是一种广谱磷脂酶 A2(PLA2) 抑制剂，也是TRP channel 的阻滞剂。ACA 也可逆的抑制钙离子激活氯通道 (calcium-activated chloride channels) ，在心律失常方面具有研究的潜力。
T0124	UK-124114 UNII-A2669OWX9N,西拉菌素,Selamectin	Others	Others
	UK-124114 (Selamectin) 是伊维菌素的大环内酯衍生物，伊维菌素是一种驱虫剂，可增强线虫中谷氨酸和 GABA 门控氯离子通道的开放。在 H. contortus 幼虫发育试验中，赛拉菌素 (0.1 µg/ml) 显示出生长抑制作用。
T1240	Flumazenil Ro 15-1788,氟马西尼	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Flumazenil (Ro 15-1788) 是一种有竞争性的GABAA 受体拮抗剂，以剂量依赖的方式逆转苯二氮卓类药物诱导的作用，包括镇静、精神运动缺陷、健忘和换气不足。
T69610	Taplucainium chloride
	Taplucainium chloride is a sodium channel blocker with applications as a pain reliever.
T69550	NS-3736
	NS-3736 is a chloride channel inhibitor that has been shown to prevent osteoclastic acidification and resorption.
T35734	Doramectin monosaccharide
	Doramectin monosaccharide is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. Doramectin undergoes acid-catalyzed hydrolysis to form doramectin monosaccharide.
T37748	Ivermectin B1b
	Ivermectin B1b is the minor component . It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function.
T61818	DFBTA
	DFBTA is a highly effective and orally active inhibitor of ANO1, specifically the calcium-activated chloride channel anoctamin-1. It exhibits potent inhibitory activity, with an IC 50 of 24 nM. Notably, DFBTA demonstrates significant analgesic efficacy in treating inflammatory pain [1].
T40750	12,14-Dichlorodehydroabietic acid
	12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity. It effectively inhibits GABA-dependent chloride influx in the mammalian brain, functioning as a non-competitive antagonist of GABA A receptors. Moreover, 12,14-Dichlorodehydroabietic acid induces an elevation in cytosolic free calcium levels and promotes the release of neurotransmitters.
TP1285	Chlorotoxin(linear)
	Chlorotoxin(linear) is a linear 36 amino-acid peptide which can be used in Chlorotoxin related research. Chlorotoxin is a chloride channel blocker which has been found in the venom of the Egyptian scorpion Leiurus quinquestriatus.
T35733	Doramectin aglycone
	Doramectin aglycone is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes, and its acid-catalyzed hydrolysis product doramectin monosaccharide . Doramectin undergoes one round of acid-catalyzed hydrolysis to form doramectin monosaccharide which is then hydrolyzed again to remove the remaining saccharide unit and form doramectin aglycone.
T37756	Phloxine B
	Phloxine B is a red dye, the USP grade of which is used as a color additive for food, drugs, and cosmetics. It has also been used as an alternative to Gram staining, to differentiate between Gram-negative and Gram-positive bacteria. At 100 μg/ml, it can inhibit methicillin-resistant S. aureus growth in vitro. Phloxine B has also been shown to modulate channel activity of wild-type cystic fibrosis transmembrane conductance regulator chloride channels (CFTR; Ki = 38 μM) and mutant delta F508 CFTR ...
T79578	CFTR corrector 12	CFTR	Membrane transporter/Ion channel
	CFTRcorrector 12（compound 17C）作为一种双噻唑衍生物，本身是CFTR校正剂。它具有校正控制氯离子跨膜运输通道的特定折叠缺陷突变的功能，并能够在带有突变的细胞中恢复α-肌聚糖（α-SG）的含量。
T35746	Milbemycin A3
	Milbemycin A3 is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin A3 is used as a nematocide and insecticide. The acaricidal and nematocidal activity of a mixture of milbemycin A3 and milbemycin A4 against adult spider mites, spider mite eggs, and C. elegans are rep...

化合物

QX-314 chloride

Cat.No: T12608

Target: Sodium Channel

Cat.No: T8960

Target: Chloride channel

Cat.No: T15192

Target: Chloride channel

Cat.No: T7638

Target: Chloride channel

Cat.No: T10979

Target: Potassium Channel, Chloride channel

Tetraethylammonium chloride

Cat.No: T7538

Target: Potassium Channel

QX-222 chloride

Cat.No: T23213

Synonym: QX 222,Lidocaine N-Methyl Hydrochloride

Target: Sodium Channel

Cesium chloride

Cat.No: T8391

Synonym: 氯化铯,CsCl

Target: Potassium Channel

Dequalinium chloride

Cat.No: T0979

Synonym: Dequafungan,地喹氯铵,Danical,Decabis

Target: Potassium Channel, PKC

Cat.No: T16346

Target: Chloride channel

Cat.No: T13059

Target: Chloride channel

Cat.No: T15233

Synonym: NS3728

Target: Chloride channel

Diphenyleneiodonium chloride

Cat.No: T7191

Synonym: 二苯基氯化碘盐,DPI

Target: NOS, Reactive Oxygen Species, NADPH, TRP/TRPV Channel

Flufenamic acid

Cat.No: T0858

Synonym: Arlef,Nichisedan,氟灭酸,氟芬那酸,Achless

Target: Potassium Channel, Calcium Channel, Chloride channel, COX, AMPK, Parasite

Cat.No: T0275

Synonym: 美替克仑,Fontiliz,Arresten,蒲硫杂茶磺胺

Target: Chloride channel, Sodium Channel

Cat.No: T2498

Synonym: AF-2364

Target: Chloride channel, Mitochondrial Metabolism

Cat.No: T4330

Target: Chloride channel

Cat.No: T0693

Synonym: 氟尼酸,Nifluril,Forenol,Landruma

Target: Others, Phospholipase, Chloride channel, COX, Monocarboxylate transporter, UGT

Oxybutynin chloride

Cat.No: T1049

Synonym: Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl

Target: Potassium Channel, AChR

Cat.No: T13536

Target: Chloride channel, GABA Receptor, Parasite

Cat.No: T4503

Synonym: Somalgen,他尼氟酯

Target: Chloride channel, COX, N-Acetylglucosaminyltransferase, Anion Exchanger

Cat.No: T22330

Synonym: N-苯基邻氨基苯甲酸,2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid

Target: Chloride channel

Cat.No: T4059

Synonym: UK-124114,司拉克丁,塞拉菌素

Target: Chloride channel, P-gp, Parasite

Cat.No: T6307

Synonym: 芦比前列酮,SPI-0211,RU-0211,鲁比前列酮

Target: Chloride channel

Emamectin Benzoate

Cat.No: T15212

Synonym: MK-244,甲胺基阿维菌素苯甲酸盐

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, Parasite

N-(p-amylcinnamoyl) Anthranilic Acid

Cat.No: T5454

Synonym: 2-(3-(4-戊基苯基)丙烯酰胺基)苯甲酸,ACA

Target: Phospholipase, TRP/TRPV Channel

Cat.No: T0124

Synonym: UNII-A2669OWX9N,西拉菌素,Selamectin

Target: Others

Cat.No: T1240

Synonym: Ro 15-1788,氟马西尼

Target: GABA Receptor

Taplucainium chloride

Cat.No: T69610

Cat.No: T69550

Doramectin monosaccharide

Cat.No: T35734

Cat.No: T37748

Cat.No: T61818

12,14-Dichlorodehydroabietic acid

Cat.No: T40750

Chlorotoxin(linear)

Cat.No: TP1285

Doramectin aglycone

Cat.No: T35733

Cat.No: T37756

CFTR corrector 12

Cat.No: T79578

Target: CFTR

Cat.No: T35746

Cat. No.	Product Name	Target	Signaling Pathways
T1221	Acetylcholine chloride ACh chloride,Pilofrin,氯化乙酰胆碱	Calcium Channel; Endogenous Metabolite; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Acetylcholine chloride (Pilofrin) 是一种神经递质，是胆碱能激动剂，通过刺激烟碱乙酰胆碱受体调节多巴胺能神经元活性，在体外抑制 p53 突变肽的聚集。
TN1035	Irisolidone 尼泊尔鸢尾异黄酮,葛花苷元	IL Receptor; NF-κB; Chloride channel	Immunology/Inflammation; Membrane transporter/Ion channel; NF-κB
	Irisolidone 是葛根花中的一种异黄酮，具有较强的保肝活性。它是一种有效的体积调节阴离子通道 (VRAC) 电流抑制剂，有高效阻断作用，IC50 为 5-13 μM。
T1125	Shikonin NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid	TNF; NF-κB; Chloride channel; HIV Protease; PKM	Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Shikonin (Anchusa acid) 属于天然产物，是一种 TMEM16A 氯离子通道抑制剂 (IC50=6.5 μM) 和选择性 PKM2 抑制剂。Shikonin 具有抗肿瘤、抗炎和伤口愈合活性。
T16535	Picrotoxinin	Chloride channel; GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Picrotoxinin 是一种氯离子通道阻断剂和 GABAA 的非竞争性拮抗剂，对 α1β2γ2L GABAA 的 IC50 为 1.15 μM。 Picrotoxinin 具有惊厥作用。
T1131	Ivermectin MK-933,伊维菌素	Mitophagy; GluCls; P2X Receptor; SARS-CoV; HIV Protease; Antibiotic; Parasite; Autophagy; HSV	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ivermectin (MK-933) 是谷氨酸门控氯离子通道激活剂，具有抗寄生虫活性。它特异性抑制Impα/β1 介导的核导入，还抑制牛疱疹病毒 1 复制并抑制BoHV-1DNA 聚合酶的核输入。它具有很强的抗病毒活性。它也是P2X4和 α7nAChRs 的正异构效应物。
T75722	Chlorotoxin TFA
	Chlorotoxin TFA，一种从蝎子毒液中分离出的多肽，作为氯离子通道 (chloride channel) 的阻断剂，具备抗癌活性。
TN1834	Kobusin 去甲槟郎碱,自旋七叶素	Others; NOS; NF-κB	Immunology/Inflammation; NF-κB; Others
	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-express...
TN3351	Aflatrem	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced

天然产物

Acetylcholine chloride

Cat.No: T1221

Synonym: ACh chloride,Pilofrin,氯化乙酰胆碱

Target: Calcium Channel, Endogenous Metabolite, AChR

Cat.No: TN1035

Synonym: 尼泊尔鸢尾异黄酮,葛花苷元

Target: IL Receptor, NF-κB, Chloride channel

Cat.No: T1125

Synonym: NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid

Target: TNF, NF-κB, Chloride channel, HIV Protease, PKM

Cat.No: T16535

Target: Chloride channel, GABA Receptor

Cat.No: T1131

Synonym: MK-933,伊维菌素

Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV

Chlorotoxin TFA

Cat.No: T75722

Cat.No: TN1834

Synonym: 去甲槟郎碱,自旋七叶素

Target: Others, NOS, NF-κB

Cat.No: TN3351

Target: GABA Receptor

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